I use all 5 browsers to design my site: IE, FF, Google Chrome, Safari and Opera. I tried to achieve the result, that my site looks exactly identical in all 5. It took a little more time and some frustration, but at the end - any of my pages looks absolutely the same in any browser.
IE8 is designed to be more Standards compliant, so my life become a little easier. Because it renders to the browser almost the same as Chrome and FF (altough there are major differences) - unlike IE7, which rendered totally different.
Based on my statistics, majority of visitors use IE - 83%, but my site is mostly targeted for the US market. 17% use all remaining browsers. Opera visitors come mostly from Europe, I guess it's popular there.
I think Google Chrome is the fastest browser than any other, especially when it comes to photos and video, but IE is faster to display dynamic data and ajax applications, when the page is already loaded, than all the rest. Also, what I like about google chrome: the tabs are working independently from each other. If one of the tabs "hanged" or frozen, you can easily continue working in another tab, without loosing anything. In IE, if 1 tab got frozen - you have to close the entire browser. Yesterday I was writing in a thread and wanted to open another tab to copy a link and this other tab got frozen, so I had to restart the whole browser and lost everything, that I was writing - that wouldn't happen in Chrome.
FF is definitely more secure than IE, but since I use the top of the line Norton Internet Security - I don't really care abt FF, because it became slower lately, because it constantly looks for updates or some gadgets. FF was more advanced than IE7, but I don't see it be any better than IE8.
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