Disable? -> Yes. Right-click your project and select 'Properties'. Then select the 'Web' tab. Deselect the internal server radio button and change it to IIS. You can run your web application from IIS. This would be more along the lines of how VS.NET 2003 worked. Read this for further information: http://forums.asp.net/t/1044279.aspx
Remove? -> I do not believe you can do this; it is a integral part of Visual Studio. Running your app from IIS, will mimic not using Cassini.
Hope this helps!