Hi,
Please make sure that the ASP.NET project's contents are copied to the virtual directory on the IIS. If you browse the page from IIS (Right click page -> select Browse), did it work?
You also need to verify if the project is configured correctly, such as ASP.NET version etc.
For more information about creating Web setup example, see http://weblogs.asp.net/scottgu/archive/2007/06/15/tip-trick-creating-packaged-asp-net-setup-programs-with-vs-2005.aspx.
I hope this helps.
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