Hello,
Are you using masterPages ? If yes, use a scriptmanagerproxy in content page.
Are you using conditional updateMode for updatePanels ? If yes, set the scriptManager as a trigger of your updatePanel on Navigate event.
If you are using both, then set the scriptManager as a trigger by code behind (you can also inherit the scriptmanager proxy and make your implementation implement the IPostBackEventHandler interface and then you can declaratively set the scriptmanagerProxy as a trigger of your updatePanels in content page).
Bye, Hope this will help
Morgan