I think I have found a solution:
1. Put your ScriptManager Control on your master page.
2. Do not register your triggers in the <Triggers> section of your update panel, but instead add the following code to your Page.Init event:
If Not Page.IsPostBack Then
Dim trigger As New Microsoft.Web.UI.AsyncPostBackTrigger
trigger.EventName = "Click"
trigger.ControlID = btnSubmit.ClientID.ToString
up1.Triggers.Add(trigger)
End If
btnSubmit is my trigger, but you can substitute whatever trigger you have on your page for this. Also, if you need to add more than one trigger, simply repeat the process in the Page.Init Event.
Please let me know if this works for you. So far, it appears to be working for me...
JDG.