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Sep 26, 2008 08:05 AM|LINK
It's extremely hard to say anything definitive in such a broad issue scope. I'll try to give some suggestions for avenues of investigation (and some that I don't think are relevant).
I don't think that it's a problem with cookies as such, since it appears to work out if you restart the browser. If cookies are disabled in the client it won't work at all, ever.
Thinking some more on it, I really think recycling might be the issue. You can check in the event log if recycling has occurred at about the same time where the users have experienced their problems.