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Dec 18, 2007 02:26 PM|LINK
Lee, I've no idea what would cause this issue. It's strange for something to work for a few days and then stop. Did you install something new in the meantime?
Have you checked the contents of the file referenced (Microsoft.WebApplication.targets)? Is it a valid XML file? It does get loaded when the project file is opened in Visual Studio, so if that was corrupted it would prevent you from opening your MVC projects.
The problem may go away if you replace that file with a new copy. You could either re-install the .NET 3.5 framework, or just copy the file from another PC.