I had the same problem when I transferred my 2.0 project from my work computer to my home computer. I was able to get rid of the "Mutex" error using the solution suggested here.
However, when I try to run it from Visual Studio, I get a compilation error: "the type initializer for 'System.Web.Compilation.CompilationLock' threw an exception."
If I tell it to run in spite of the error, it runs and there does not seem to be any problem, but it's a little disturbing. Why would I be getting this on my home computer and not on my work computer? Both computers have the same version of Visual Studio.
Has anyone else run into this error?