I have noticed recently that my admin->site settings takes a long time to load. I realized it is the same problem as I documented on Scott's forum:
http://www.smcculloch.net/Forums/tabid/118/forumid/4/postid/4942/view/topic/Default.aspxBasically, this url control does some file access stuff on my portal. And my portal has tons of directories and files (photos) in it. I removed all controls and references in the codebehind in sitesettings.ascx and sitesettings.ascx.vb and it loads instantly. For some portals, this NEVER loads. Sometimes a couple mins or more.
See my post above for details on my system setup.
<%@ Register TagPrefix="Portal" TagName="URL" Src="~/controls/URLControl.ascx" %>
Jason