There is a technology called WebDAV which will let you serve office files and let them be opened in excell or word and then saved back to the server from excel or word.
If you want the spreadsheets to be editable via the website then you are going to be looking at buying a commercial component.
It depends on what level of control you have over the environment - are they all going to be xls files, or xlsx (2007) files? are they going to contain calculations or just straight data? if the requirements are simple then you might be able to attempt writing your own xls loader, convert it to database format and then allow editing and then allow export to xls....