Jackxxx:This project has AJAX used in almost every page. So would it be better to remove the scriptManagers from the individual pages and only have the one in the MasterPage?
Absolutey. You can do that.
As long as you are using Ajax control throughout your web app, it is better to keep ScriptManager in Master page, which is called on each and every page.
I can't see any performance overhead in doing so.