Hi Greg,
KB928365 contains an update for the validators but it's not in the release notes. We had a problem with one of our validations that is now fixed with this release.
In an update panel, after the initial page load, we've multiple textboxes which are hooked up to one validator with the function 'ValidatorHookupControlID'.
When an ajax postback is triggered, some of the textboxes are removed, but the validators array still contains the removed controls. So when you want to go the next page, it want's to validate all the controls, but some are gone. So you get a 'not defined' JavaScript error.
Greets.