Much like a previous post i made when using Toolkit controls... now I am getting it just using ScriptManager and some PageMethod callbacks

Surely someone out there has gotten this error and might have some tips on what to do about it?
The problem is pretty intermittent, and when it does rear it's ugly head, it takes about 4-5 refreshes of the page to actually work... there is absolutely no rhyme or reason.... no code was changed from working to not working and back to working, just simple F5 page resfreshes....